Pyrrolobenzodiazepines

US7407951B2 · kind B2 · utility

Assignee

• SPIROGEN LIMITED · GB

Inventors

• David Edwin Thurston · Stapleford, GB
• Philip Wilson Howard · London, GB

Key dates

• Filing date: Nov 14, 2003
• Grant date: Aug 5, 2008
• Expiry date: Nov 14, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I): formula (I) and salts, solvates, chemically protected forms, and prodrugs thereof, are disclosed wherein R2 is selected from: an optionally substituted napthyl group; an optionally substituted thiophenyl or furanyl group; and a phenyl group substituted by: one or more chloro or fluoro groups; an ethyl or propyl group; a 4-t-butyl group; a 2-methyl group; or two methyl groups in the 2- and 6-positions.