Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof

US7407963B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Wolfgang Eberlein · Biberach, DE
• Wolfhard Engel
• Klaus Rudolf · Warthausen, DE
• Henri Doods · Warthausen, DE
• Gerhard Hallermayer · Biberach an der Riß, DE
• Eckhart Bauer · Biberach, DE

Key dates

• Filing date: Jun 27, 2005
• Grant date: Aug 5, 2008
• Expiry date: Jun 27, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of general formula (I)wherein R and R1 are as defined herein, or a tautomer, diastereomer, enantiomer, or salt thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing the compound, their use, and processes for preparing them.