Oligo or polyalkylene glycol-coupled thrombin inhibitors

US7407982B2 · kind B2 · utility

Assignee

• HaemoSys GmbH · DE

Inventors

• Torsten Steinmetzer · Jena, DE
• Gotz Nowak · Erfurt, DE

Key dates

• Filing date: Jan 23, 2002
• Grant date: Aug 5, 2008
• Expiry date: May 20, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P7/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel covalent oligo and polyalkylene glycol conjugates with synthetic inhibitors of trypsin-type serine proteases, in particular inhibitors of the hemocoagulation protease thrombin, synthetic intermediates stages required in their production and their use for producing active ingredients for the treatment or prophylaxis of thrombotic complications.