Therapeutic Agents

US7407990B2 · kind B2 · utility

Assignee

• Knoll, Inc. · DE

Inventors

• Graham Paul Luscombe · Nottingham, GB
• Patricia Needham · Mansfield, GB

Key dates

• Filing date: Feb 2, 2007
• Grant date: Aug 5, 2008
• Expiry date: Feb 2, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P39/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted cycloalkyl compounds with 3 to 6 carbon atoms in the ring, one carbon linked to each of two side groups R and R′, and pharmaceutically acceptable salts thereof in which R is phenyl optionally substituted by one or more halo substituents or R is naphthyl; and R′ is —[X—Y—S(O)m-Z-N—R1—R2], wherein X is carbonyl or a carbon directly linked to each of a hydroxyl group and R5 in which R5 is H or alkyl, Y is an alkylene chain optionally substituted by one or more alkyl groups, m can be 0, 1 or 2, Z is an alkylene chain containing 2 to 5 carbon atoms optionally substituted by one or more alkyl groups, and R1 and R2, which are the same or different, are H, alkyl, or arylalkyl, provided that when R1 is benzyl, R2 is H or methyl; have utility in the treatment of drug misuse or other addictive disorders.