Modulators of the glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7411071B2 · kind B2 · utility
3Cited by
17References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 12, 2006 |
| Grant date | Aug 12, 2008 |
| Priority date | — |
| Expiry date | May 9, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I):where X is S, O or N; Z is —T—COOR1 or —T—COR1; and T, R, R1, Ra, Rb, Rc, Rd, Z, A and B are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.