Patent · US Expired

Nanofibrous biocomposite prosthetic vascular graft

US7413575B2 · kind B2 · utility

42Cited by
3References
42Claims
0Family size

Inventors

Key dates

Filing dateAug 25, 2005
Grant dateAug 19, 2008
Priority date
Expiry dateApr 22, 2026

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61F2/06
  • WIPO fieldMedical technology
  • WIPO sectorInstruments

Abstract

The present invention provides a bioactive, small-diameter (typically less than 6 mm in internal diameter) vascular graft prosthesis, and is a textile conduit preferably manufactured using a novel electrospinning perfusion methodology. One preferred embodiment is a nanofibrous biocomposite textile conduit which comprises a prepared liquid admixture of polyester (Dacron), a biodurable implantable synthetic polymer, and Type IV collagen, an extracellular matrix protein. This prepared admixture and blending of diverse fibrous matter is utilized in a novel electrospinning perfusion process to form a small-diameter (less than 6 mm) fabricated textile conduit, a discrete article of manufacture, which then serves as an antecedent tangible workpiece for a subsequently-made prosthetic vascular graft construct.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.