Process for producing solid oral dosage forms with sustained release of active ingredient

US7413750B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Karl Kolter · Ludwigshafen am Rhein, DE
• Dieter Flick · Ludwigshafen, DE
• Hermann Ascherl · Dirmstein, DE

Key dates

• Filing date: Jun 5, 2001
• Grant date: Aug 19, 2008
• Expiry date: Jun 5, 2021

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/2027
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for producing solid oral dosage forms with sustained release of active ingredient, comprising at least one active ingredient, a preformulated mixture of polyvinyl acetate and polyvinylpyrrolidone, where appropriate, water-soluble polymers or lipophilic additives and, where appropriate, other conventional excipients, wherein this mixture or parts of this mixture are granulated by heating to from 40° C. to 130° C., and the granules are, after admixture with conventional excipients, subsequently tabletted.