Aldolases, nucleic acids encoding them and methods for making and using them
US7414119B2 · kind B2 · utility
10Cited by
7References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 19, 2003 |
| Grant date | Aug 19, 2008 |
| Priority date | — |
| Expiry date | Sep 28, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/12
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R-(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.