Process for manufacture of 4-amino-hydroxybutylidene-1, 1-bisphosphonic acid and its salts
US7414151B2 · kind B2 · utility
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6References
18Claims
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Key dates
| Filing date | Dec 27, 2006 |
| Grant date | Aug 19, 2008 |
| Priority date | — |
| Expiry date | Dec 27, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/3873
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The preset invention relates to a cost effective, high yielding, reproducible method for the manufacture of alendronic acid or its salt, such as sodium alendronate, from inexpensive and readily available pyrrolidone using phosphonating agents such as PCl3 in the presence of acids such as sulphonic acids, sulphuric acid or phosphoric acid, and pharmaceutical dosage forms of alendronic acid or pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.