Transgenic bovines capable of human antibody production
US7414170B2 · kind B2 · utility
11Cited by
100References
39Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 19, 2003 |
| Grant date | Aug 19, 2008 |
| Priority date | — |
| Expiry date | Apr 10, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/208
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention features novel methods for the production of large quantities of xenogenous antibodies, such as human antibodies. Preferably, this result is effected by inactivation of IgM heavy chain expression and, optionally, by inactivation of Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of xenogenous antibodies (e.g., non-bovine antibodies), preferably human antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.