PD-1-lacking mouse and use thereof
US7414171B2 · kind B2 · utility
40Cited by
1References
3Claims
0Family size
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Key dates
| Filing date | Nov 14, 2001 |
| Grant date | Aug 19, 2008 |
| Priority date | — |
| Expiry date | Sep 21, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0375
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to BALB/c mice that are deficient in the programmed cell death-1 receptor (PD-1), a screening method for autoimmune disease medicine using these mice, an IgG self-reactive antibody that the mice produce, a protein that specifically reacts to the antibody and is produced in heart, and a diagnostic method for dilated cardiomyopathy using the protein. Because PD-1 deficient BALB/c mice spontaneously develop autoimmune disease, and specifically dilated cardiomyopathy, they are useful for screening for medicines against these diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.