Template-fixed peptidomimetics as inhibitors of serine proteases
US7417024B2 · kind B2 · utility
12Cited by
0References
4Claims
0Family size
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Key dates
| Filing date | Dec 11, 2001 |
| Grant date | Aug 26, 2008 |
| Priority date | — |
| Expiry date | Aug 15, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Template-fixed β-hairpin peptidomimetics of the general formulae (I), wherein Z is a template-fixed chain of 7 to 11 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formulae, are defined in the description and the claims, and salts thereof, have the property to inhibit proteases, in particular serine proteases. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.