Modulators of dopamine neurotransmission

US7417043B2 · kind B2 · utility

Assignee

• NeuroSearch Sweden AB · SE

Inventors

• Bengt R. Andersson · Göteborg, SE
• Susanna Waters · Handen, SE
• Nicholas Waters · Handen, SE
• Joakim Tedroff · Danderyd, SE
• Clas Sonesson · Lindome, SE

Key dates

• Filing date: Dec 21, 2004
• Grant date: Aug 26, 2008
• Expiry date: Dec 21, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A 3-substituted 4-(phenyl-N-alkyl)-piperazine compound of the following formula:wherein R1 is selected from the group consisting of OSO2CF3, OSO2CH3, SO2R3, COCF3, COCH3 and COCH2CH3, wherein R3 is as defined hereafter; R2 is selected from the group consisting of C1-C4 alkyls, allyl, CH2CH2CH2F, CH2CF3, 3,3,3-trifluoropropyl and 4,4,4-trifluorobutyl; R3 is selected from the group consisting of C1-C3 alkyls, CF3, and N(CH3)2; with the proviso that when R1 is SO2R3 and R3 is a C1-C3 alkyl, then R2 is not CH2CH2OCH3; or a pharmaceutically acceptable salt thereof are provided. Also, pharmaceutical compositions comprising the above compound and methods wherein the above compound is used for the treatment of various disorders are provided.