Biodegradable polyphosphoramidates for controlled release of bioactive substances
US7417110B2 · kind B2 · utility
Inventors
Key dates
| Filing date | May 14, 2002 |
| Grant date | Aug 26, 2008 |
| Priority date | — |
| Expiry date | May 14, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a series of new polycationic biodegradable polyphosphoramidates. Process for making the polymers, compositions containing these polymers and bioactive ligands to enhance the cellular uptake ad intracellular trafficking, articles and methods for delivery of drugs and genes using these polymers are described. A gene delivery system based on these polymers is prepared by complex coacervation of nucleic acid (DNA or RNA) with polymers. Targeting ligands and molecules that could facilitate gene transfer can be conjugated to polymers to achieve selective and enhanced gene delivery. The current invention also provides a complex composition with buffering capacity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.