Antibodies specific for CD44v6

US7417127B2 · kind B2 · utility

Assignees

• Boehringer Ingelheim Pharmaceuticals, Inc. · US
• Bohringer Ingelheim International GmbH · DE

Inventors

• Gunther Adolf · Wien, AT
• Elinborg Ostermann · Mauerbach, AT
• Erik Patzelt · Purkersdorf, AT
• Marlies Sproll · Gauting, DE
• Karl-Heinz Heider · Stockerau, AT
• John J. Miglietta · Bethel, US
• Augustinus Antonius Maria Silvester Van Dongen · Utrecht, NL

Key dates

• Filing date: May 25, 2005
• Grant date: Aug 26, 2008
• Expiry date: Oct 1, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/021
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.