Process for the preparation of Montelukast
US7417149B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 3, 2006 |
| Grant date | Aug 26, 2008 |
| Priority date | — |
| Expiry date | Feb 3, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of Montelukast and the salts thereof comprising the following steps:(a) reaction of a compound Awith a compound A2in which n varies between 1 and 2 and, when n is 1, R is methyl and, when n is 2, R is a C1-C4 alkyl or an aryl, and X is a leaving group, by nucleophilic substitution reactions in dipolar organic solvents to yield the compound A3(b) reaction of the compound A3 with an inorganic acid HY, in which Y is Cl, Br, I, and subsequent isolation of the resultant salt A4;(c) optional conversion of the salt A4 into the compound A3;(d) methylation of the salt A4 and/or of the compound A3 to yield Montelukast.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.