Screening for ligand binding at specific target sites
US7419835B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 21, 2003 |
| Grant date | Sep 2, 2008 |
| Priority date | — |
| Expiry date | Jan 9, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/2575
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for screening of compounds for binding differentiation at various drug target binding sites is used with a device measuring the enthalpy of reaction for the binding. The method includes merging test ligand with target compound and merging test ligand with target compound in the presence of at least one blocking agent. A first heat of reaction is detected for the merged test ligand and target compound solution and a second heat of reaction is detected for the merged test ligand and target compound solution in the presence of a blocking agent. The two heats of reaction are compared to determine whether a reaction has occurred.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.