D-pyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture

US7419959B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthias Eckhardt · Hannover, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Peter Eickelmann · Mittelbiberach, DE
• Leo Thomas · Biberach, DE
• Edward Barsoumian · Toyonaka, JP

Key dates

• Filing date: Sep 30, 2005
• Grant date: Sep 2, 2008
• Expiry date: Dec 9, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

D-pyranosyl-substituted phenyls of general formula Iwherein the groups R1 to R5, X, Z and R7a, R7b, R7c are defined as in claim 1, have an inhibiting effect on the sodium-dependent glucose cotransporter SGLT. The present invention also relates to pharmaceutical compositions for the treatment of metabolic disorders.