Nucleotide lipid ester derivatives

US7419965B2 · kind B2 · utility

Assignee

• Heidelberg Pharma GmbH · DE

Inventors

• Dieter Herrmann · Kirchzarten, DE
• Brigitte Heckl-Oestreicher · Heidelberg, DE
• Christoph Mueller · Birkenau, DE
• Christian Lutz · Kassel, DE
• Robert C. Voigt · State College, US
• William E. Bauta · San Antonio, US

Key dates

• Filing date: Mar 18, 2004
• Grant date: Sep 2, 2008
• Expiry date: Jun 19, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject of the present invention is specific lipidesters of halogenated nucleotides of the following formulawherein R1, R2, R3, X and Y are defined as described herein and salts thereof, said compounds have anti-cancer properties; pharmaceutical compositions containing the compounds, a method of synthesizing the compounds, and a method of using the compounds for treating malignant tumors.