2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1

US7419972B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Alexander Hillisch · Solingen, DE
• Olaf Peters · Bad Tabarz, DE
• Christian Gege · Ehingen (Donau), DE
• Wilko Regenhardt · Munich, DE
• Andrea Rosinus · Munich, DE
• Jerzy Adamski · Munich, DE
• Gabriele Moeller · Munich, DE
• Walter Elger · Berlin, DE
• Birgitt Schneider · Jena, DE
• Ulrich Bothe · Berlin, DE

Key dates

• Filing date: Jun 17, 2005
• Grant date: Sep 2, 2008
• Expiry date: Jun 17, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J1/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to new 2-substituted estra-1,3,5(10)-trien-17-ones of formula Ias well as their pharmaceutically acceptable salts, their methods of manufacture and use as medicaments for prophylaxis and/or therapy of estrogen-dependent diseases that can be influenced by the inhibition of 17β-hydroxy steroid dehydrogenase type 1.