Gonadotropin-releasing hormone receptor antagonists and methods related thereto

US7419983B2 · kind B2 · utility

Assignee

• Neurocrine Biosciences, Inc. · US

Inventors

• Zhiqiang Guo · San Diego, US
• Yongsheng Chen · Shanghai, CN
• Dongpei Wu · San Diego, US
• Chen Chen · San Diego, US
• Warren Wade · San Diego, US
• Wesley J. Dwight · San Diego, US
• Charles Huang · San Diego, US
• Fabio Tucci · San Diego, US

Key dates

• Filing date: Jan 25, 2007
• Grant date: Sep 2, 2008
• Expiry date: Jan 25, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.