Gamma lactams as prostaglandin agonists and use thereof

US7419999B2 · kind B2 · utility

Assignee

• APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

Inventors

• Gian Luca Araldi · Plymouth, US
• Adulla P. Reddy · Walpole, US
• Zhong Zhao · Munich, DE
• Sean D. McKenna · Duxbury, US
• Bagna Bao · Sharon, US

Key dates

• Filing date: Jun 9, 2003
• Grant date: Sep 2, 2008
• Expiry date: Jul 3, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing preterm labor, dysmenorrhea, asthma, hypertension, infertility or fertility disorder, undesired blood clotting, preeclampsia or eclampsia, an eosinophil disorder, sexual dysfunction, osteporosis and other destructive bone disease or disorder, renal dysfunction, an immune deficiency disorder, dry eye, ichthyosis, elevated intraocular pressure, sleep disorder, or gastric ulcer, inflammatory disorders and other diseases and disorders associated with the prostaglandin family of compounds.