Synthetic process for the manufacture of an ecteinaschidin compound
US7420051B2 · kind B2 · utility
16Cited by
13References
16Claims
0Family size
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Key dates
| Filing date | Oct 11, 2005 |
| Grant date | Sep 2, 2008 |
| Priority date | — |
| Expiry date | Jun 9, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D515/22
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxyl, di-6,8-en-5-one fused ring compound. After formation of the 1,4 brige, C-18 protection is removed before spiroamine introduction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.