Patent · US Expired

Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof

US7420078B2 · kind B2 · utility

1Cited by

2References

9Claims

0Family size

Assignee

Ciba Specialty Chemicals Corporation · US

Inventors

Reinhold Öhrlein · Rheinfelden (Baden), DE
Gabriele Baisch · Binzen, DE
Nicole End · Oberwil, CH
Stephan Burkhardt · Gelterkinden, CH
Martin Studer · Basel, CH

Key dates

Filing date	Jul 2, 2002
Grant date	Sep 2, 2008
Priority date	—
Expiry date	Jan 2, 2024

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH3)OCH3, Ra is a hydroxy-protecting group, and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.