Hepatitis-B viral variants with reduced susceptibility to nucleoside analogs and uses thereof
US7422848B2 · kind B2 · utility
10Cited by
1References
8Claims
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Inventor
Key dates
| Filing date | Mar 15, 2006 |
| Grant date | Sep 9, 2008 |
| Priority date | — |
| Expiry date | Mar 15, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/106664
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues, both in vivo and in vitro. More in particular, reverse transcriptase mutant rtA181S is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti-viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.