Patent · US Expired

Method for discrimination of metaplasias from neoplastic or preneoplastic lesions

US7422859B2 · kind B2 · utility

8Cited by

3References

15Claims

0Family size

Assignee

MTM Laboratories, AG · DE

Inventors

Ruediger Ridder · Schriesheim, DE
Magnus Von Knebel Doeberitz · Heidelberg, DE
Peter Martin · Far Hills, US

Key dates

Filing date	Apr 8, 2003
Grant date	Sep 9, 2008
Priority date	—
Expiry date	May 23, 2024

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/025
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to a method for discrimination of p16INK4a overexpressing metaplasias from neoplastic or preneoplastic p16INK4a overexpressing lesions by determination of the level of high risk HPV encoded gene-products such as e.g. HPV E2 and/or HPV E7 molecules in biological samples in the course of cytological testing procedures. The method thus enables for reduction of false positive results in the p16INK4a based detection of anogenital lesions in cytological testing procedures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.