Compounds and compositions as protein kinase inhibitors

US7423038B2 · kind B2 · utility

Assignee

• IRM LLC, a Delaware Limited Liability Company · BM

Inventors

• Pingda Ren · San Diego, US
• Xia Wang · San Diego, US
• Nathanael S. Gray · Boston, US
• Yi Liu · San Diego, US
• Taebo Sim · San Diego, US

Key dates

• Filing date: Jun 23, 2005
• Grant date: Sep 9, 2008
• Expiry date: Jun 23, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders than involve abnormal activation of the Abl, Bcr-abl, Bmx, c-RAF, CSK, Fes, FGFR3, Flt3, GSK3β, IR, JNK1α 1, JNK2α 2, Lck, MKK4, MKK6, p70S6K, PDGFRα, Rsk1, SAPK2α, SAPK2β, Syk and Trkβ kinases.