Patent · US Active

Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones

US7423146B2 · kind B2 · utility

1Cited by

5References

21Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

Marco Santagostino · Magenta, IT
Werner Rall · Mittelbiberach, DE
Rainer Soyka · Biberach, DE

Key dates

Filing date	Oct 25, 2006
Grant date	Sep 9, 2008
Priority date	—
Expiry date	Oct 25, 2026

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process for making a compound of formula 1or a salt thereof, wherein: wherein R4 is benzyl, diphenylmethyl, or trityl, each optionally substituted at, if available, an aryl group or an aliphatic carbon atom, with a compound of formula 7or a salt thereof, to obtain a compound of formula 5, or a salt thereof(b) reducing the nitro group of the compound of formula 5 to an amine group and mesylating this amine group and cleaving the protecting group during the reduction step or after the mesylation step to obtain the compound of formula 1.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.