Alphavirus replicon vector systems
US7425337B2 · kind B2 · utility
36Cited by
53References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 16, 2006 |
| Grant date | Sep 16, 2008 |
| Priority date | — |
| Expiry date | Mar 16, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/206
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides compositions useful in and methods for producing populations of infectious, replication-defective alphavirus replicon particles that contain no replication competent alphavirus particles, as determined by passage on cells in culture. The compositions include helper and replicon nucleic acid molecules that can further reduce the predicted frequency for formation of replication-competent virus and can optimize manufacturing strategies and costs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.