HAUSP-p53 interaction and uses thereof
US7425538B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 30, 2002 |
| Grant date | Sep 16, 2008 |
| Priority date | — |
| Expiry date | Sep 20, 2022 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides methods for determining whether a subject has neoplasia, methods for assessing the efficacy of therapy to treat neoplasia in a subject, methods for assessing the prognosis of a subject who has neoplasia, and methods for treating neoplasia in a subject in need of treatment. The present invention further provides a kit for use in detecting neoplasia. Additionally, the present invention provides a pharmaceutical composition, comprising a modulator of HAUSP expression or a HAUSP protein and a pharmaceutically acceptable carrier. Also provided is a method for deubiquitinating p53 in a cell. The present invention is further directed to a method for identifying an agent that is reactive with p53, and the agent identified by this method. Furthermore, the present invention provides a method for treating a p53-associated condition in a subject in need of treatment. The present invention is also directed to a complex comprising p53 and HAUSP, and a mutant protein comprising the HAUSP amino acid sequence, in which Ser is substituted for Cys at amino acid residue 223. Finally, the present invention provides a transgenic non-human animal whose genome comprises a di…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.