Benzofuran oxyethylamines as antidepressants and anxiolytics

US7425574B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Gunter Holzemann · Seeheim-Jugenheim, DE
• Kai Schiemann · Darmstadt, DE
• Henning Bottcher · Darmstadt, DE
• Timo Heinrich · Groß-Umstadt, DE
• Christoph Seyfried · Seeheim-Jugenheim, DE
• Joachim Leibrock · Gauting, DE
• Chrisoph Van Amsterdam · Darmstadt, DE
• Gerd Bartoszyk · Weiterstadt, DE

Key dates

• Filing date: Jan 19, 2004
• Grant date: Sep 16, 2008
• Expiry date: May 17, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel benzofuranoxyethylamines of the formula (I), in which R1, R2, R3, R4, m and n have the meanings indicated in Patent Claim (1), which have a strong affinity to the 5 HT1A receptors and/or 5HT1D receptors. The compounds inhibit serotonin reuptake, exhibit serotonin-agonistic and -antagonistic properties and are suitable as antidepressants, anxiolytics, antipsychotics, neuroleptics and/or antihypertonics.