Carboxylic acid amides, the preparation thereof and their use as pharmaceutical compositions

US7425641B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Uwe Ries · Biberach an der Riß, DE
• Henning Priepke · Warthausen, DE
• Armin Heckel · Biberach an der Riß, DE
• Herbert Nar · Ochsenhausen, DE
• Wolfgang Wienen · Äpfingen, DE
• Jean-Marie Stassen · Bad Buchau, DE

Key dates

• Filing date: Sep 10, 2004
• Grant date: Sep 16, 2008
• Expiry date: Sep 10, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to carboxylic acid amides of general formulawherein The compounds of the above general formula I wherein R5 denotes a cyano group are valuable intermediate products for preparing the other compounds of general formula I, and the compounds of the above general formula I wherein R5 denotes one of the amidino groups mentioned in claim 1 have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.