Biodegradable poly(β-amino esters) and uses thereof
US7427394B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 28, 2003 |
| Grant date | Sep 23, 2008 |
| Priority date | — |
| Expiry date | Apr 17, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08L99/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.