Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them

US7427611B2 · kind B2 · utility

Assignee

• Solvay Pharmaceuticals, GmbH · US

Inventors

• Dagmar Hoeltje · Gehrden, DE
• Yvan Fischer · Barsinghausen, DE
• Dieter Ziegler · Hemmingen, DE
• Michael Weske · Burgdorf, DE
• Katrin Michaelis · Hannover, DE
• Yasmin Karimi-Nejad · Hannover, DE
• Josef Messinger · Sehnde, DE
• Axel Pahl · Winsen (Aller), DE
• Constanze Hoefer · Hannover, DE
• Hrissanthi Ikonomidou · Berlin, DE
• Lechoslaw Turski · Berlin, DE

Key dates

• Filing date: Apr 17, 2006
• Grant date: Sep 23, 2008
• Expiry date: May 20, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06139
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity corresponding to the formula I,wherein the substituents R1, R2, R3 and R4 have the meanings given in the description and also pharmaceutical compositions containing these compounds, in particular pharmaceutical compositions suitable for treating or inhibiting cardiovascular diseases, sexual dysfunction and/or adverse conditions associated with apoptosis.