Ethynyl derivatives as factor Xa inhibitors

US7427618B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Werner Mederski · Zwingenberg, DE
• Christos Tsaklakidis · Weinheim, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Bertram Cezanne · Mörfelden, DE
• Johannes Gleitz · Darmstadt, DE
• Christoph van Amsterdam · Darmstadt, DE

Key dates

• Filing date: Jan 30, 2004
• Grant date: Sep 23, 2008
• Expiry date: Aug 25, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6533
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds of the formula (I), in which R1, R2, R3, X and Y have the meaning indicated in Patent claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.