Precursors for two-step polynucleotide synthesis
US7427679B2 · kind B2 · utility
63Cited by
7References
9Claims
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Key dates
| Filing date | Aug 30, 2003 |
| Grant date | Sep 23, 2008 |
| Priority date | — |
| Expiry date | Nov 11, 2024 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Precursors for use in the synthesis of polynucleotides are disclosed. The precursors include a heterocyclic base having an exocyclic amine group and a substituted or unsubstituted triaryl methyl protecting group bound to the exocyclic amine group. In particular embodiments, the precursor has the structure:wherein: wherein the broken line represents a bond to the amino nitrogen of the exocyclic amine group, and R4, R5 and R6 are independently selected from unsubstituted or substituted aryl groups, provided that at least one of R4, R5, and R6 is an aryl group other than phenyl and other than substituted phenyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.