Quantitative broadband absorption and scattering spectroscopy in turbid media by combined frequency-domain and steady state methodologies
US7428434B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 9, 2002 |
| Grant date | Sep 23, 2008 |
| Priority date | — |
| Expiry date | Apr 2, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/4312
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A technique for measuring broadband near-infrared absorption spectra of turbid media that uses a combination of frequency-domain and steady-state reflectance methods. Most of the wavelength coverage is provided by a white-light steady-state measurement, whereas the frequency-domain data are acquired at a few selected wavelengths. Coefficients of absorption and reduced scattering derived from the frequency-domain data are used to calibrate the intensity of the steady-state measurements and to determine the reduced scattering coefficient at all wavelengths in the spectral window of interest. The absorption coefficient spectrum is determined by comparing the steady-state reflectance values with the predictions of diffusion theory, wavelength by wavelength. Absorption spectra of a turbid phantom and of human breast tissue in vivo, derived with the combined frequency-domain and steady-state technique, agree well with expected reference values.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.