Patent · US Expired

Potassium channel mutants of the yeast Saccharomyces cerevisiae and their use for screening eukaryotic potassium channels

US7429449B2 · kind B2 · utility

1Cited by

1References

9Claims

0Family size

Assignee

Sanofi-Aventis Deutschland GMBH · DE

Inventors

Ekkehard Leberer · Germering, DE
Thomas Leeuw · Greifenberg, DE
Allegra Ritscher · Birkenfeld, DE

Key dates

Filing date	Jan 11, 2001
Grant date	Sep 30, 2008
Priority date	—
Expiry date	Jan 11, 2021

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P43/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to processes for identifying inhibitors and activators of eukaryotic potassium channels, in which a mutated S. cerevisiae cell is used whose endogenous potassium channels TRK1, TRK2 and TOK1 are not expressed functionally, but which expresses heterologously a eukaryotic potassium channel to be studied. Other subject matters of the invention are mutated S. cerevisiae cells which do not express TRK1, TRK2 and TOK1, and the preparation and use of these mutated S. cerevisiae cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.