Patent · US Active

Method for diagnosing a transmissible spongiform subacute encephalopathy caused by an unconventional transmissible agent strain in a biological sample

US7429463B2 · kind B2 · utility

0Cited by

4References

21Claims

0Family size

Assignee

COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES · FR

Inventors

Jean-Philippe Deslys · Le Chesnay, FR
Emmanuel Comoy · Le Plessis-Robinson, FR
Jacques Grassi · Les Ulis, FR

Key dates

Filing date	Sep 14, 2005
Grant date	Sep 30, 2008
Priority date	—
Expiry date	Sep 2, 2026

Classification

Technology area (CPC G)Physics
CPC primaryG01N2800/2828
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention relates to a method for diagnosing a transmissible spongiform subacute encephalopathy (TSSE) caused by an unconventional transmissible agent (UTA) or prion. The method involves treating a sample suspected of containing a prion with proteinase K for a time and under conditions that completely degrade normal prion protein (Prp-sen), but which only partially digest abnormal prion protein (PrP-res) so that all or some of the octapeptide motif repeats comprising P(H/Q)GGG(-/T)WGQ (SEQ ID NO: 1) in the abnormal prion protein (Prp-res) are retained.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.