Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions

US7429597B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Henning Priepke · Warthausen, DE
• Roland Pfau · Biberach, DE
• Kai Gerlach · Biberach, DE
• Uwe Ries · Biberach an der Riß, DE
• Wolfgang Wienen · Äpfingen, DE
• Eckhart Bauer · Biberach, DE
• Herbert Nar · Ochsenhausen, DE

Key dates

• Filing date: Dec 18, 2003
• Grant date: Sep 30, 2008
• Expiry date: Oct 15, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to new substituted nitrogen-containing heterobicyclic compounds of general formulawherein B, X1 to X3 and R1 to R5 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.The compounds of the above general formula I as well as the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, and their stereoisomers have valuable pharmacological properties, particularly an antithrombotic activity and a factor Xa-inhibiting activity.