TRPV1 agonists, formulations containing them and uses thereof

US7429673B2 · kind B2 · utility

Assignee

• INDENA S.P.A. · IT

Inventors

• Paolo Morazzoni · Milano, IT
• Antonella Riva · Milano, IT
• Gabriele Fontana · Milano, IT
• Giovanni Appendino · Michendorf, DE
• Vincenzo Di Marzo · Pozzuoli, IT

Key dates

• Filing date: Jul 6, 2005
• Grant date: Sep 30, 2008
• Expiry date: Jul 6, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D303/46
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene: R2 is a C6-C12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of pathologies mediated by vanilloid receptors type I.