Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions

US7432262B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Matthias Eckhardt · Hannover, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Iris Kauffmann-Hefner · Biberach an der Riß, DE
• Elke Langkopf · Biberach an der Riß, DE
• Mohammad Tadayyon · Hertford, GB
• Leo Thomas · Biberach, DE

Key dates

• Filing date: Feb 16, 2007
• Grant date: Oct 7, 2008
• Expiry date: Feb 16, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to substituted imidazopyridazinediones of general formulawherein R1 to R4 are defined as in claim 1, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).