Gossypol co-crystals and the use thereof
US7432300B2 · kind B2 · utility
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19References
10Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 15, 2007 |
| Grant date | Oct 7, 2008 |
| Priority date | — |
| Expiry date | Jun 15, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to compositions comprising co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (−)-gossypol with a C1-8 carboxylic acid or C1-8 sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.