Photolabile protecting groups

US7432368B2 · kind B2 · utility

Assignee

• ROCHE NIMBLEGEN, INC. · US

Inventor

• Klaus-Peter Stengele · Pleiskirchen, DE

Key dates

• Filing date: Apr 20, 2005
• Grant date: Oct 7, 2008
• Expiry date: Aug 31, 2026

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to novel nucleoside derivatives of general formula (I)wherein R1=H, halogen, NO2, CN, OCH3, an alkyl, alkoxy or alkoxyalkyl residue having 1 to 4 C atoms, preferably a methyl, ethyl, propyl or butyl residue or an optionally substituted aryl residue or aliphatic acyl residue having 2 to 5 atoms, R2 to R7=H, NO2, CN, OCH3, a branched or unbranched alkyl, alkoxy or alkoxyalkyl residue having 1 to 5 C atoms or an optionally substituted aryl residue or an aliphatic acyl residue having 2 to 5 atoms, X is the group C═O or C═S, Y═S, O, NR′, C(R′)2, wherein R′ is H, or a branched or unbranched alkyl residue having 1 to 5 C atoms or an optionally substituted aryl residue, Z=SO2, OCO, OCS, SCS, and N is a nucleotide.