Pyridine derivatives

US7435743B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Toshiki Murata · Nara, JP
• Masaomi Umeda · Nara, JP
• Sachiko Sakakibara · Nara, JP
• Takashi Yoshiro · Nara, JP
• Hiroki Sato · Nara, JP
• Tsutomu Masuda · Amagasaki, JP
• Yuji Koriyama · Kusatsu, JP
• Mitsuiyuki Shimada · Meerbusch, DE
• Takuya Shintani · Kyoto, JP
• Hiroshi Kadono · Kasai, JP
• Timothy B. Lowinger · Carlisle, US
• Karl Ziegelbauer · Wuppertal, DE
• Kinji Fuchikami · Kyoto, JP
• Hiroshi Komura · Nara, JP

Key dates

• Filing date: Sep 30, 2005
• Grant date: Oct 14, 2008
• Expiry date: May 13, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D515/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyrimidine compounds of general formula:wherein —R1 representsin which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl, C1-6 alkylamino, di (C1-6 alkyl)amino, C1-6 alkanoylamino, phenyl C1-6 alkylamino, phenylsulfonylamino, or —O—(CH2)n—R111; R2 represents hydrogen or halogen; R3 represents hydrogen, —CR31R32R33; R4 is hydrogen, carbamoyl, CN, carboxyl, etc.; R5 is amino, C1-6 alkylamino, di C1-6 alkylamino, etc. or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.