TNF-α binding molecules
US7435799B2 · kind B2 · utility
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79References
2Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 8, 2004 |
| Grant date | Oct 14, 2008 |
| Priority date | — |
| Expiry date | Feb 16, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to TNF-α binding molecules and nucleic acid sequences encoding TNF-α binding molecules. In particular, the present invention relates to TNF-α binding molecules with a high binding affinity, a high association rate, a low dissociation rate with regard to human TNF-α and that are capable of neutralizing TNF-α at low concentrations. Preferably, the TNF-α binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.