Compounds and methods of use

US7435823B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Michele Potashman · Cambridge, US
• Tae-Seong Kim · Yongin-si, KR
• Steven Bellon · Wellesley, US
• Shon Booker · Thousand Oaks, US
• Yuan Cheng · Newbury Park, US
• Joseph L. Kim · Wayland, US
• Andrew Tasker · Simi Valley, US
• Ning Xi · Newbury Park, US
• Shimin Xu · Beijing, CN
• Jean-Christophe Harmange · Poissy, FR
• George Borg · Somerville, US
• Matthew Weiss · Boston, US
• Brian L. Hodous · Cambridge, US
• Russell Graceffa · Hampton, US
• William H. Buckner · Arlington, US
• Craig E. Masse · Cambridge, US
• Deborah Choquette · Medford, US
• Matthew W. Martin · Arlington, US
• Julie Germain · Medford, US
• Lucian V. DiPietro · Gloucester, US
• Stuart C. Chaffee · Philadelphia, US
• Joseph J. Nunes · Andover, US
• John L. Buchanan · Brookline, US
• Gregory Habgood · Merrimac, US
• David Craig McGowan · Vilvoorde, BE
• Douglas A. Whittington · Waltham, US
• Daniel La · Brookline, US
• Vinod F. Patel · Acton, US

Key dates

• Filing date: Jan 24, 2005
• Grant date: Oct 14, 2008
• Expiry date: Jul 13, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.