Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates

US7435861B2 · kind B2 · utility

Assignee

• Cardax Pharmaceuticals, Inc. · US

Inventors

• Samuel Lockwood · Lake Linden, US
• Peng Cho Tang · Moraga, US
• Geoff Nadolski · Kaaawa, US
• Henry Jackson · Honolulu, US
• Zhiqiang Fang · 流花街道, CN
• Yishu Du · Shanghai, CN
• Min Yang · Vernon Hills, US
• William B. Geiss · Athens, US
• Richard Williams · Newbury Park, US
• David Burdick · Guilderland, US

Key dates

• Filing date: May 1, 2006
• Grant date: Oct 14, 2008
• Expiry date: May 1, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.