Patent · US Expired

Screening assay based on the forkhead transcription factor-dependent sod-3 promoter

US7435868B2 · kind B2 · utility

0Cited by

1References

32Claims

0Family size

Assignee

Sanofi-Aventis Deutschland GMBH · DE

Inventors

Edmund Hoppe · Krailling, DE
Ulrike Siebers · Munich, DE
Heike Schauerte · Munich, DE
Jonathan Rothblatt · Bound Brook Junction, US

Key dates

Filing date	Jan 28, 2004
Grant date	Oct 14, 2008
Priority date	—
Expiry date	Oct 27, 2025

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6897
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to the identification and use of the DAF-2/IR responsive sod-3 promoter. Transgenic C. elegans containing sod-3 reporter gene constructs are described which are useful for, among other things, the identification of genes or compounds capable of modulating the DAF-2/IR-akt pathway. Conditions are disclosed that increase or decrease the reporter activity, demonstrating the presence of either activators or inhibitors of the DAF-2/IR pathway.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.