Independent helper virus packaging cell line for propagating viral vectors
US7439060B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 24, 1998 |
| Grant date | Oct 21, 2008 |
| Priority date | — |
| Expiry date | Mar 24, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14152
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided are novel vectors and viral vectors capable of expressing exogenous gene or exogenous nucleic acid sequences in a target cell of interest, such as T cells, bone marrow cells, epithelial cells, liver cells and the like. The nucleic acid components of the vectors may include one or more native promoter/enhancer regions having modified sequence segments, one or more non-native promoter/enhancer or non-native promoter's gene or gene segment, and a native viral vector terminator or processing signal or segment thereof. The viral vectors comprise a virus or viral portion having on the surfaces or envelopes adsorption components, one for a packaging cell line and the other for delivery to a target cell. Packaging cell lines for propagating the vectors and viral vectors are also provided, as are novel processes for propagating any of the disclosed vectors or viral vectors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.